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According to a report from Al Jazeera TV station on January 1st, a new study published on Wednesday, January 29th, has raised concerns about the long-standing belief in the medical community regarding vitamin E and beta-carotene. The research suggests that these antioxidants may actually speed up the growth of lung cancer cells—especially in individuals at high risk, such as smokers—rather than protecting them as previously thought.
Bill Linder, a biologist at the University of Gothenburg in Sweden, who is involved in research on "antioxidants and cancer cell activity," explained that "antioxidants can help cancer cells bypass the body's natural anti-tumor defenses." This means that existing cancer cells can spread more rapidly, and even small, undetectable tumors may grow faster under the influence of these substances.
Martin Birgu, another researcher from the same university, also participated in the study. He warned that excessive use of antioxidant supplements could be harmful, potentially accelerating tumor growth. He stated, “If I have a lung cancer patient, I would never recommend they take antioxidants.â€
It is important to note that the study’s findings do not apply to natural foods rich in antioxidants, such as fruits and vegetables. The results are specifically relevant to antioxidant supplements, not the nutrients found in whole foods. The researchers emphasized that their conclusions were based solely on synthetic supplements, not on dietary sources.
The study, published in *Science Translational Medicine*, did not find evidence that antioxidants cause lung cancer directly, but it did show that they can increase the rate at which cancer cells grow. It also did not investigate the effects of naturally occurring antioxidants in food.
This research adds to a growing body of evidence challenging the idea that taking vitamin supplements is beneficial for everyone, especially those who are not malnourished. While antioxidants do neutralize free radicals in laboratory settings—these are unstable molecules that can damage DNA and other cellular components—the real-world impact may be more complex.
In the 1980s, antioxidants became widely popular due to the belief that they could protect DNA from free radical damage and prevent diseases like cancer. However, this latest study highlights that the benefits may be overestimated.
In the experiment, scientists tested vitamin E and another antioxidant on mice with early-stage lung cancer. The dose of vitamin E used was equivalent to what people typically take as a supplement, while the second antioxidant was administered in lower amounts. The results showed that mice given antioxidants had 2.8 times more cancer cells than those that didn’t receive the treatment. These cancer cells became more aggressive and led to quicker deaths.
Additionally, the antioxidants accelerated the growth of cancer cells in lab cultures. One of the key contributions of this study is its method for investigating how antioxidants interact with cancer cells. While antioxidants may reduce some cellular damage, the effect is smaller than expected. Their protective role is also limited compared to the P53 protein, a critical defense mechanism against cancer.
Under normal conditions, when the P53 system is damaged (such as by UV exposure), it triggers the death of potentially cancerous cells. However, the study found that when cancer cells escape this system, antioxidants can promote tumor growth. This discovery raises important questions about the safety of antioxidant supplements and their role in cancer progression.